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CHOUDHARY LABORATORY


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Deciphering cell signaling networks through innovative proteomics.

ABOUT US

The Choudhary Laboratory is a research group consisting of 10 international researchers with diverse academic background and expertise in biochemistry, cell signaling, genome editing, and quantitative mass spectrometry.

The Group is interested in systematically deciphering the code of cellular communication system (cell signaling networks) by applying innovative proteomic, genomic, and cell biological technologies.

We are located at the Novo Nordisk Foundation Center for Protein Research (CPR), at the Faculty of Health and Medical Sciences at the University of Copenhagen.

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RESEARCH INTEREST


A major focus of the Group is to obtain novel understanding of the regulatory mechanisms in cell signaling through `systems-wide` investigations of signaling networks. In particular, we are interested in unraveling the properties and the regulatory landscape of posttranslational modifications (PTMs) in signaling networks. PTMs have crucial roles in the dynamic regulation of protein activity, stability, spatial localization, and communication with other macromolecules within cells. PTMs are directly relevant for human health as dysregulation of PTM modifying enzymes, such as protein kinases, ubiquitin ligases, and lysine deacetylases, is frequently associated with human disease.

Our laboratory applies cutting-edge mass spectrometry-based proteomics technologies for unbiased, global, and quantitative analysis of key regulatory PTMs, such as lysine acetylation and ubiquitylation. The laboratory has state-of-the-art facilities for work related to cell biology, biochemistry, and genome editing, and has access to in-house infrastructure and expertise for live cell imaging, flow cytometry, the next generation nucleic acid sequencing, and protein biophysical analyses. The unique combination of the Group´s expertise and collaboration with leading researchers from Denmark and around the world distinctively positions the group to investigate the functional relevance of PTMs in diverse biological contexts.

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